MULTIVARIATE META-ANALYSIS OF GENETIC ASSOCIATION STUDIES: A SIMULATION STUDY.

In a meta-analysis with multiple end points of interests that are correlated between or within studies, multivariate approach to meta-analysis has a potential to produce more precise estimates of effects by exploiting the correlation structure between end points.However, under random-effects assumption the multivariate estimation is more complex (a

Recent advances in recombinant adeno-associated virus (rAAV) gene therapy for choroideremia show gene replacement to be a promising approach.It is, however, well known that contact of vector solution with plastic materials in the surgical device may result in non-specific adsorption with resulting loss of physical titer and/or level of protein expr